BACKGROUND Implant anchorage in highly osteoporotic bone is challenging, since it often leads to osteosynthesis failure in geriatric patients with supracondylar femoral fractures. Cementation of screws is presumed to prevent such osteosynthesis failure. This study aimed to investigate the effect of a newly designed, cementable fenestrated condylar screw for plate fixation in a biomechanical setting. METHODS Eight pairs of osteoporotic cadaver femora with an average age of 77?years, ranging between 62 and 88?years, were randomly assigned to either an augmented or a non-augmented group. In both groups an instable&nbsp;33-A3 fracture according to the AO / OTA classification was fixed with an angular stable locking plate. All right samples received a cement augmentation of their fenestrated condylar screws with calcium phosphate bone cement (CPC). Mechanical testing was performed at a load to failure mode by cyclic axial loading, using a servohydraulic testing machine. RESULTS With a mean of 2475?N (95% CI 1727-3223?N), the pressure forces resulting in osteosynthesis failure were significantly higher in specimen with cemented condylar screws as compared to non-cemented samples (1875?N (95% CI 1320-2430?N)) (p?=?0.024). In both groups the deformation of the constructs, with the distal screws cutting through the condylar bone, were the most frequent cause for failure. Analysis of axial stiffness (p?=?0.889) and irreversible deformity of the specimens revealed no differences between the both groups (p?=?0.161). No cement leakage through the joint line or the medial cortex was observed. CONCLUSION Based on the present study results, the newly introduced, cementable condylar screw could be an encouraging feature for the fixation of supracondylar femoral fractures in patients with reduced bone quality in terms of load to failure accuracy of the cement application.BACKGROUND Hyperhomocysteinemia (HHCY) is a risk factor for cardiovascular and cerebrovascular diseases. The C677T 5, 10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphism increases homocysteine (HCY) levels. This study analyzed the relationship between C677T MTHFR polymorphism and the therapeutic effect of lowering HCY in stroke patients with HHCY. METHODS Baseline data were collected from stroke patients with HHCY for this prospective cohort study. The C677T MTHFR genotype was detected by polymerase chain reaction-restriction fragment length polymorphism and the therapeutic effect to reduce HCY was compared. RESULTS Of 200 stroke patients 162 (81.0%) completed follow-up and were evaluated. Most of them responded well to treatment (103 cases, 63.5%), but 59 (36.4%) patients were in the poor efficacy group. There was a significant difference in terms of age (P? less then ?0.001), hypertension (P?=?0.041), hyperuricemia (P?=?0.042), HCY after treatment (P? less then ?0.001), and MTHFR genotype (P? less then ?0.001) between the poor efficacy and effective groups, with increased frequency of the TT genotype in the poor efficacy group. Logistic regression showed that the T allele was associated with poor efficacy (OR?=?0.733, 95%CI 0.693, 0.862, P? less then ?0.001). In the codominant model the TT genotype was associated with poor outcome (OR?=?0.862, 95%CI 0.767, 0.970, P?=?0.017) and this was also the case in the recessive model (OR?=?0.585, 95%CI 0.462, 0.741, P? less then ?0.001) but there was no association between CT and TT in the dominant model. CONCLUSIONS The T allele and TT genotype of the MTHFR C677T polymorphism was associated with poor HCY reduction treatment efficacy in stroke patients with HHCY. TRIAL REGISTRATION The registration number of the clinical trial is ChiCTR1800020048. Registration date December 12, 2018.INTRODUCTION Dental profession has expanded, and the knowledge that oral health affects systemic health is of greater concern to patients. The purpose of this study is to understand the demand for dental treatments in Italy, knowing if there is any correlation between socioeconomic condition and oral rehabilitation typology. Moreover, focusing on the requested rehabilitations type and on finding alternatives, unconventional solutions. MATERIALS AND METHODS The research was conducted using an important research database defined Google Trends, with search parameters such as "tooth pain". A statistical analysis has been conducted in this study evaluation Pearson Correlation Coefficient. RESULTS The results divided region by region provide data that reflect the socio-economic conditions of the population concerned. Other results have been obtained from government source, to learn about the economic situations of the individual regions, for this reason the GDP was examined. Furthermore, there are important results regarding the parasanitary professions to which patients, for economic reasons, tend to refer. CONCLUSIONS This study will surely be an excellent starting point to investigate professional abuse and above all to assess the needs of the different regions.BACKGROUND To correlate fluorescence based camera (FC), visual inspection (ICDAS-II) and radiographic examination x-rays bitewings (BW) to the extent of caries after excavation. METHODS The occlusal sites of 20 permanent first and second molars in 14 young adolescents (12±2 y.o.) were examined at 1st Observation Unit of Department of Oral and Maxillofacial Sciences, "Sapienza" University of Rome. All the enrolled patients were asked to provide with x-rays bitewing of the studied teeth. The assessment of ICDAS-II and FC was performed by a trained operator. Then a second blind operator removed the carious lesion and evaluated the cavity extent (depth, width, length) after caries removal with a calibrated probe. To correlate FC measurements with bitewing sensitivity, 10 dentists evaluated the presence/absence of caries on the x-rays. RESULTS All the occlusal sites assessed by fluorescence camera, ranged from 1.7 to 2, indicating in all cases deep enamel lesions with possible extent to dentine with a mean of 1.7+0. In accordance, visual inspection by ICDAS-II showed scores of 3 and 4. By contrast, the radiographic documentation, ie. bitewing x-rays, was evaluated in only 6 cases as presence of caries. The extent of the cavities was determined by three consecutive measurements depth, width and length, with a mean of 3.5+1.73, 2.8+1.07 and 3.2+1.64 mm respectively. These results confirmed the agreement between FC and ICDAS-II for diagnosis of cavities with extent to enamel and dentine, while showed the low sensitivity of bitewings x-rays, in accordance with the existing evidence in Literature. https://www.selleckchem.com/products/3-deazaneplanocin-a-dznep.html Moreover, the results of this study for the first time provide information about the cavity extent after caries removal for the occlusal sites with ICDAS-II 3 and 4 scores and FC &gt;=1.7. CONCLUSIONS X-rays evaluation showed diagnostic accuracy in 6% of the sample. VistaCam measurement of 1.7 was correlated to a cavity with 3.5, 2.8 and 3.2 mm of depth, width and length.